Irritable Bowel Syndrome Research Today is a free monthly online journal that collates and summarizes the latest research about Irritable Bowel Syndrome, including details on treatment, symptoms, digestion, nutrition, diet, drugs.
Mucosal immune cell numbers and visceral sensitivity in patients with irritable bowel syndrome: is there any relationship?
Braak B, Klooker TK, Wouters MM, Welting O, van der Loos CM, Stanisor OI, van Diest S, van den Wijngaard RM, Boeckxstaens GE
Department of Gastroenterology and Hepatology, AMC, Amsterdam, The Netherlands.
Published 7 May 2012 in Am J Gastroenterol, 107(5): 715-26.
Articles on Irritable Bowel Syndrome published 3 May 2012:
Irritable bowel syndrome and the elusive mast cells. Am J Gastroenterol, 107(5): 727-9.
Irritable bowel syndrome (IBS) is the most common condition seen by gastroenterologists. It presents with alternating symptoms of bowel dysfunction that often worsens with stress. The cause of these symptoms eludes investigators and many attempts have been made to discover an underlying pathology. This is a daunting task since symptoms come and go, and change characteristics. Furthermore, the pathology of IBS is unlikely to be identical in all patients. In addition, all symptoms and all ... [Abstract] [Full-text]
The jejunum of diarrhea-predominant irritable bowel syndrome shows molecular alterations in the tight junction signaling pathway that are associated with mucosal pathobiology and clinical manifestations. Am J Gastroenterol, 107(5): 736-46.
Colonic transit time and IBS symptoms: what's the link? Am J Gastroenterol, 107(5): 754-60.
Lower serum IL-10 is an independent predictor of IBS among volunteers in Mexico. Am J Gastroenterol, 107(5): 747-53.
Articles on Irritable Bowel Syndrome published 2 May 2012:
SERT and TPH-1 mRNA expression are reduced in irritable bowel syndrome patients regardless of visceral sensitivity state in large intestine. Am J Physiol Gastrointest Liver Physiol, 302(9): G1053-60.
Colorectal visceral hypersensitivity has been demonstrated in a subset of irritable bowel syndrome (IBS) patients. Serine protease and serotonergic signaling modulate gastrointestinal visceral sensitivity. We evaluated whether altered mucosal serine protease and serotonergic pathway components are related to rectal visceral hypersensitivity in IBS patients. Colorectal mucosal biopsies of 23 IBS patients and 15 controls were collected. Gene transcripts of protease-activated receptor (PAR)-2, ... [Abstract] [Full-text]
Articles on Irritable Bowel Syndrome published 24 April 2012:
Pharmacogenetics of the effects of colesevelam on colonic transit in irritable bowel syndrome with diarrhea. Dig Dis Sci, 57(5): 1222-6.
Anti-stress effects of transcutaneous electrical nerve stimulation (TENS) on colonic motility in rats. Dig Dis Sci, 57(5): 1213-21.
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