Irritable Bowel Syndrome Research Today is a free monthly online journal that collates and summarizes the latest research about Irritable Bowel Syndrome, including details on treatment, symptoms, digestion, nutrition, diet, drugs. | ||||||||
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Hypersensitivity to cutaneous thermal nociceptive stimuli in irritable bowel syndrome.Rodrigues AC, Nicholas Verne G, Schmidt S, Mauderli AP Department of Neuroscience, University of Florida, P.O. Box 100435, Gainesville, FL 32610-0435, USA. Irritable bowel syndrome (IBS) is a common intestinal ailment of which the pathophysiological mechanisms are not well understood. Most IBS patients demonstrate enhanced perception, visceral hypersensitivity, in response to distension of the gut lumen but there are conflicting results about changes in somatic sensitivity. This study focused on the possible contribution of abnormal pain sensitization due to positive feedback (vicious pain cycle) that affects somatic tissues due to viscero-somatic convergence. The specific objectives were to measure cutaneous thermal pain sensitivity along the segmental axis, including in dermatomes that are remote from the visceral pain focus. Pain sensitivity was probed with cutaneous thermal stimulation to the lower and upper extremities and the face in nine diarrhea-predominant IBS patients (diagnosed with ROME II criteria) and 12 healthy female controls. The stimuli were administered with a contact thermode, assuring that size of the stimulated area and stimulus duration were clearly defined and identical in all locations. Sensitization of IBS patients was not limited to symptomatic dermatomes (calf) but extended evenly across the body, including to the face (no sensitization gradient from foot to face). Also, the difference between IBS and control groups did not depend on the evoked pain intensity level, i.e. the degree of sensitization of IBS patients was similar near threshold (10% on the visual analog scale) and at higher intensities. Lastly, no correlation was found between IBS subjects' pain sensitivity of any of the three test sites and their ratings of spontaneous pain. Published 19 April 2005 in Pain, 115(1): 5-11.
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